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#326483 - 06/10/20 06:41 AM Re: covid-19 cure [Re: jgw]
NW Ponderer Offline
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Carpal Tunnel

Registered: 09/09/11
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I'm from Missouri.

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#326498 - 06/10/20 07:37 PM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
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Registered: 02/27/06
Posts: 10124
Loc: North San Diego County
BTW, I'm in touch with GreatNewsTonight. His immediate family is fine, but his brother had very mild Covid-19 but just ended up in the hospital with a stroke a week later. This is a VERY BAD VIRUS, folks. You want to avoid this at all costs, if possible. Trump's idea of just letting everyone catch it would result in millions of dead and many more crippled for life.

Wear those masks, and not pulled down off your nose. Use eye protection. Keep social distance. Wash your hands often after touching anything out in public, or after removing your mask once home.

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#326579 - 06/12/20 08:23 PM Re: covid-19 cure [Re: jgw]
jgw Online   content
enthusiast

Registered: 05/22/06
Posts: 3451
Loc: Port Angeles, WA
There are the vaccines and then there are the treatments. Thought I would check out treatments and here are a couple of results(I restricted the results to the last 24 hours):

https://www.beckersasc.com/supply-chain/5-covid-19-treatment-contenders-how-they-work.html
https://www.rockefeller.edu/news/28238-llama-nanobodies-covid-19-research/

Its interesting. If you google for covid-19 vaccine, for just the last 24 hours, you will get page after page. If, however, you look for "covid-19 treatment" there is only two replies.

I did it again, this time for the last week and found more:
https://www.medscape.com/viewarticle/932181
https://www.forbes.com/sites/jamesconca/...n/#3ea0bf9fdc69
https://www.healthline.com/health-news/h...ts-for-covid-19

On the face of it treatments are few and far between and all seem to be either in tests or have been tested and don't work. Vaccines, it seems, may be ahead of the treatments so far but there are treatment coming up and are being tested. I am just hoping to last long enough so that, if I get it, there will actually be a treatment that works whilst waiting for the vaccine to come on line. (I think treatment may be available before a vaccine due to testing requirements).



Edited by jgw (06/12/20 08:31 PM)

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#326583 - 06/13/20 05:48 AM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
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Registered: 02/27/06
Posts: 10124
Loc: North San Diego County
There are some useful prophylactic measures that are very safe to take and easy to find. These are things you can find in your local drug store, health food store, or on Amazon. None of them are cures, but they can make your body much more resistant so if you do get it you have a much better chance of having a mild case.

First of all, Vitamin D: Take 4000 iu per day, and if you have a deficiency take 10000 iu per day for two weeks to build up your stores. There are some scientific papers that support this.

Next would be zinc and quercetin: 50 mg per day is the highest recommended dose for zinc, but if you do get sick you could up that to 100 mg/day. Quercetin is pretty safe. About 500 mg twice a day.

Vitamin C: 500 mg twice per day, because why not? Couldn't hurt.

NAC: If you have any symptoms at all, take 600 mg of N-acetyl-cysteine. Very good to prevent clotting and jack up your anti-oxidents.

Meletonin: 2-3 mg just before bed. Good sleep is very important for your immune system.

Pepcid: May block an enzyme the virus needs. One study suggested this because way more people on Prilosec as opposed to Pepcid got hospitalized.

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#326588 - 06/13/20 05:27 PM Re: covid-19 cure [Re: pondering_it_all]
jgw Online   content
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Registered: 05/22/06
Posts: 3451
Loc: Port Angeles, WA
thanks for the thought. I am taking most of those every day, except for meletonin and pepcid.

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#326592 - 06/13/20 09:37 PM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
veteran

Registered: 02/27/06
Posts: 10124
Loc: North San Diego County
I've started taking meletonin, and I find I sleep a lot better and always fall asleep quicker. Apparently high doses of Vitamin D can give some people insomnia. I just noticed that happening recently.

I just got some generic pepcid. It's extremely cheap, and it might help, so it's nice to have. I probably won't take it unless I start to get sick. Stomach acid is actually a pretty good defense against a lot of pathogens.

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#326632 - 06/15/20 07:39 PM Re: covid-19 cure [Re: jgw]
jgw Online   content
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Registered: 05/22/06
Posts: 3451
Loc: Port Angeles, WA

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#326635 - 06/15/20 10:14 PM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
veteran

Registered: 02/27/06
Posts: 10124
Loc: North San Diego County
Interesting, that first article reports a combination of antivirals that might be useful. But like all antivirals, they would have to be given very early to do any good. Hopefully, they do a Phase 3 trial somewhere like Brazil where they have a lot of community spread and then give it out to a lot of people with first symptoms.

The other interesting thing they report is finding a lot of recovered people are not making the long-lasting IgG antibodies. So if you use 2 month old recovered plasma it may not help sick people. That does not mean the recovered patient could catch it again. The virus is in their B-cell memory, so they could make a lot of IgG quickly. They just never had to, because the short term IgM took care of it. This matches nicely with the reported finding of others that many recovered patients were not "sero-converting" (making IgG).

The second URL is nice, because it's for a drug to treat the later, autoimmune phase of a serious infection. If we had a really good treatment for that, it would knock the death rate a lot. And the patients who could use it are very obvious, unlike antiviral candidates.

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#326647 - 06/16/20 05:33 PM Re: covid-19 cure [Re: jgw]
jgw Online   content
enthusiast

Registered: 05/22/06
Posts: 3451
Loc: Port Angeles, WA
I also read someplace that they are starting to close in on what makes some people more likely to get very sick but have not net nailed it down. This is, I think, a really good thing! (especially if they figure it out)

I am more interested in treatments and who gets what than the vaccines which I suspect are going to take a bit more time. The good news is that they seem to be making progress. I have, incidentally, not posted anything about Ayurveda medicine, its a bit strange.

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#326652 - 06/16/20 07:44 PM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
veteran

Registered: 02/27/06
Posts: 10124
Loc: North San Diego County
Random assigned study out of Oxford reported today, not peer reviewed or published yet but it will be. They said dexamethasone (common steroid) given to sick and very sick Covid-19 patients cuts mortality by up to 1/3. Actually the East Virginia Medical School protocol has been suggesting steroids for the inflammatory autoimmune phase of serious illness for quite some time, but it's nice to have a random trial to confirm it.

I was a little surprised that the MedCram doc at UC Riverside was not using steroids for all his sick patients, since he's been posting a lot about the serious phase being endothelial inflammation, and steroids would be one obvious treatment for that. He said WHO said not to use steroids a while back, but now with this study I suspect a lot of docs will use them. WHO has said a lot of stuff that later turns out to be wrong, but the docs have had to learn as they go.

I think this is more support for the theory that says the virus causes serious oxidative stress, resulting in superoxide and hydrogen peroxide which attacks the endothelium (lining of the blood vessels). This releases some super clotting stuff call Von Willibrand's Factor (VWF) that forms long chains to build blood clots. All the serious lung, heart, and other organ failure is caused by those micro-clots clogging the capillaries.

NAC can steer the immune system away from inflammation, reduce those oxygen radicals, and breakup VWF chains. Speaking of Ayurvedic Medicine, curcumin is actually a pretty powerful antioxidant. It would be worth looking into.

One of the more interesting things to come out of this, is that many of these treatments and prophylactics are not SARS-COV2 specific. They might work against other viruses as well. For example, they know about NAC for what it does for flu patients. It does not have any effect on who catches flu, but it makes it much less serious. Worth having it around in the future, and you can buy it over-the-counter.

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