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#325994 - 05/23/20 06:55 PM Re: covid-19 cure [Re: jgw]
jgw Offline
enthusiast

Registered: 05/22/06
Posts: 3353
Loc: Port Angeles, WA
China promises their covid-19 vaccine to the world
https://www.bloombergquint.com/quicktake...ld-go-quicktake

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#325999 - 05/23/20 10:00 PM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
veteran

Registered: 02/27/06
Posts: 10000
Loc: North San Diego County
Even if the Oxford vaccine failed, they have the infrastructure and Big Pharma connections in place. When they get a hold of one that does work (from some university or non Big Pharma rival) they can run with it. There are so many vaccines in the works, it's highly likely they can license one that does work.

I've done some antibody production work for research purposes, decades ago. It isn't all that difficult. We succeeded in making horse and goat anti-dog lymphocyte antibodies and failed when we tried to make rabbit anti-morphine antibody.

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#326015 - 05/24/20 10:43 AM Re: covid-19 cure [Re: pondering_it_all]
GreatNewsTonight Offline
newbie

Registered: 04/27/20
Posts: 264
Originally Posted By: pondering_it_all
Even if the Oxford vaccine failed, they have the infrastructure and Big Pharma connections in place. When they get a hold of one that does work (from some university or non Big Pharma rival) they can run with it. There are so many vaccines in the works, it's highly likely they can license one that does work.

I've done some antibody production work for research purposes, decades ago. It isn't all that difficult. We succeeded in making horse and goat anti-dog lymphocyte antibodies and failed when we tried to make rabbit anti-morphine antibody.


I wouldn't be so sure of the "highly likely" part. Remember, a virus that hasn't mutated much, the HIV, has been elusive to all vaccine efforts for 30 years. And the coronaviruses that are responsible for part of the common cold collective, do not seem very prone to being susceptible to vaccines, either. The SARS an MERS vaccines never got going and had safety issues.

Sure, we all hope for a safe and effective vaccine, but will we get one? It's still up in the air.
_________________________
Please take COVID-19 seriously; don't panic but don't deny it; practice social distancing (stay 6ft from people); wash your hands a lot, don't touch your face, don't gather with too many people, so that you help us contain it.

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#326018 - 05/24/20 06:04 PM Re: covid-19 cure [Re: pondering_it_all]
jgw Offline
enthusiast

Registered: 05/22/06
Posts: 3353
Loc: Port Angeles, WA
The Oxford vaccine did fail but they are now back to the drawing boards and forward with phase 1 again!

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#326097 - 05/26/20 02:23 AM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
veteran

Registered: 02/27/06
Posts: 10000
Loc: North San Diego County
One of the other DNA virus efforts just reported they made several different vaccines from different parts of the spike protein. They tested on monkeys (like Oxford) and ALL vaccine recipients developed IgG. Some vaccines were VERY effective. Then they challenged the vaccinated monkeys with large viral loads. None got sick. The very effective vaccine ones never had any measurable virus. The less effective vaccine ones had asymptomatic cases with positive PCR throat swabs.

So I think we got this, as far as monkeys go.

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#326102 - 05/26/20 09:19 AM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
veteran

Registered: 02/27/06
Posts: 10000
Loc: North San Diego County
Nice Science article came out today that reported T-cells responding to Covid-19 infections. That's pretty good news because T-cells are associated with life-long immunity.

The other nice thing they reported is that testing old pre-Covid-19 blood samples, they found a good chunk of them contained antibodies that responded to some SARS-COV2 surface proteins. They hypothesized this was because those proteins were shared with the other four corona virus strains that circulated world-wide as common colds over the last 15 years. This may well explain why most kids have asymptomatic infections, if they had one of those colds. It also explains why some kids (who never encountered any of the four harmless corona viruses) can get very sick and even die. Kids in daycare and school are very likely to get such colds, which explains why young people usually do not have bad cases. This very same generational pre-exposure effect happened in 1918 also.

I actually hypothesized this very same thing, when I read that some antibody test makers warned their takers that exposure to one of those four strains could cause false positives. Not totally false, as it turns out!

This actually means we have four ready-made "cowpox" viruses we could use to give people immunity to this "smallpox", just like the very first vaccinations ever used.

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#326103 - 05/26/20 03:36 PM Re: covid-19 cure [Re: jgw]
perotista Offline
journeyman

Registered: 09/05/19
Posts: 644
Here's something to think about. It helps explain the political differences between the two major parties in keeping things closed and reopening back up.

From the article.

"The devastation, in other words, has been disproportionately felt in blue America, which helps explain why people on opposing sides of a partisan divide that has intensified in the past two decades are thinking about the virus differently. It is not just that Democrats and Republicans disagree on how to reopen businesses, schools and the country as a whole. Beyond perception, beyond ideology, there are starkly different realities for red and blue America right now."

"The Coronavirus Is Deadliest Where Democrats Live"

https://www.yahoo.com/news/coronavirus-deadliest-where-democrats-live-121518089.html

I can see the difference here where I live. My county has been relative unscathed. Reopening most things seems appropriate. Now those in and around the Atlanta area, that might be considered crazy. Well over half of all cases and deaths in Georgia have occurred in and around Atlanta. Atlanta heavily Democratic, the rest of Georgia, pretty much Republican.

Based on the article, it is easy to see and understand the huge political difference between parties in keeping things closed and reopening.
_________________________
It's high past time that we start electing Americans to congress and the presidency who put America first instead of their political party. For way too long we have been electing Republicans and Democrats who happen to be Americans instead of Americans who happen to be Republicans and Democrats.

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#326104 - 05/26/20 05:09 PM Re: covid-19 cure [Re: perotista]
Greger Offline


Carpal Tunnel

Registered: 11/24/06
Posts: 16930
Loc: Florida
My mostly rural county is the same. Relatively unscathed. We know it's out there and that we might catch it and die. But we needn't live in fear of it. Most everyone is wearing masks except in the poor people store where I occasionally shop. Maybe half wear masks there and some employees don't.

But the craziness from the right is....well, crazy.

Quote:
A viral social media post falsely claims Dr. Anthony Fauci is “pushing” remdesivir as a potential COVID-19 treatment drug, because he “invented” it with Bill Gates and they stand to profit from it.
_________________________
Good coffee, good weed, and time on my hands...

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#326122 - 05/26/20 11:32 PM Re: covid-19 cure [Re: jgw]
pondering_it_all Offline
veteran

Registered: 02/27/06
Posts: 10000
Loc: North San Diego County
Relatively unscathed....so far. The virus doesn't care if you are Democrat or Republican, city dweller or rural. If you mix with people who have it, you will get it, and if your local medical facilities are few and unsophisticated, you could die. You could die anyway. Open everything up without masks, and you WILL have an outbreak. Maybe we can get to a second hundred thousand dead.

The new case count does not depend on your zip code. The virus is exactly the same. The shape of the curve is exactly the same when people don't maintain distance and wear masks. If you think you are invulnerable because of your rural location, you are going to be sadly disappointed. Many of the major outbreaks currently are in rural locations that thought it wouldn't come there. The whole US numbers look like they are going down, but that's mostly New York. If you remove New York, the numbers are still going up.

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#326126 - 05/27/20 01:32 AM Re: covid-19 cure [Re: pondering_it_all]
Greger Offline


Carpal Tunnel

Registered: 11/24/06
Posts: 16930
Loc: Florida
Most of us rural folks don't do all that much mixing in the best of times.
_________________________
Good coffee, good weed, and time on my hands...

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