So that's why dialysis patients die. Much more complicated than I thought.

I have a weird condition where I often have sugar in my urine, but I never have a positive A1C. If I eat a lot of sugar, my kidney's seem to piss it out very efficiently. This has always been the case, from childhood. I have a familial history of diabetes. I also have peripheral afferent neuropathy (numb feet) from myelin degeneration.

My neurologist says neuropathy is not a symptom of my MS. Is it possible to have diabetic neuropathy without a positive A1C? Or do I just have an autoimmune reaction to myelin?

To top that off, my wife has an undiagnosed (or rather multiple different diagnoses) autoimmune condition against maybe connective tissue? Maybe against something else?

There is a possibility that both of our problems are the same unknown pathogen since she was a Veterinary Pathologist and could have been exposed to something weird that I caught. Her problem could be an unknown parasite since artemisia seems to help her cyclic episodes.

Idiopathic Glycosuia

Idiopathic peripheral neuropathy, is common and is diagnosed by ruling out toxin exposure, lead, paint, etc and DM. The nerves to the feet are the longest in the body, and is a long supply line vulnerable to many many insults. So not DM neuropathy. CNS and PNS myelin are different, so doubt autoimmune neuropathy related to MS.

Some autoimmune conditions are related to molecular mimicry when some bacteria or virus resembles a human tissue antigen and mistakenly gets attacked!

Obviously I have a lot of relatively harmless defects. Renal glycosuria sounds like a winner. I am a little concerned about this:



The problem is that doctors always look at A1C to tell if you have DM, but the renal glycosuria prevents a positive A1C! The two conditions could be unrelated, but having one prevents diagnosis of the other.

The defect would likely prevent the complications of DM, as it's the long term elevation of serum glucose that causes all the problems to, vascular, renal, and nerves! In fact one of the newer treatments, i furget the trade name, is a medication that blocks the renal
re-absorption of glucose. and dumps glucose into the urine, improving the serum glucose levels.

Google to the rescue!

Canagliflozin, Dapagliflozin, and Empagliflozin, OH MY! That's why I couldn't remember their names, I would never waste brain RAM on a bunch of, pardon the term, Copycat drugs!

Cool! So I already have that capability without the expensive prescription.



I was hoping that was the case, but sometimes what we hope for is not the total situation.

On another good news topic, I like to watch TWIV (This Week In Virology) on YouTube. Once a week they hear from Dr. Griffin who is a honcho of docs treating Covid-19 patients every day. This week he mentioned the benefits of treating admitted patients with 25(OH)-Vitamin D, as discussed by the Spanish trials. He also mentioned this later when he was discussing GPs treating Covid19 outpatients instead of just sending them home to isolate until they either get better or worse and need hospitalization.

He also said people who get vaccinations and soon after discover they have been exposed right around that time, tend to do better than those who don't get vaccinations. So immunity may not begin much before 14 days post vaccination, but apparently just giving your immune system a few days jump on it's response is useful.

Some do that now with people bitten by rabid animals on the extremities, since the immune system can be faster than the rabies virus getting into the central nervous system. Facial bites are more urgent. They require quick treatment with antibodies.