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Coronavirus: The Plague of The 21st Century?
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What's for dinner?
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Winning
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"Mom, I think it's a boy."
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You don't know beans! vs Killer Beans
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Moderna trying to ignore 1.5 billion dollar investment
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The other side of shipping
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Geoengineering
by TatumAH - 11/18/21 04:35 AM
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So that's why dialysis patients die. Much more complicated than I thought.

I have a weird condition where I often have sugar in my urine, but I never have a positive A1C. If I eat a lot of sugar, my kidney's seem to piss it out very efficiently. This has always been the case, from childhood. I have a familial history of diabetes. I also have peripheral afferent neuropathy (numb feet) from myelin degeneration.

My neurologist says neuropathy is not a symptom of my MS. Is it possible to have diabetic neuropathy without a positive A1C? Or do I just have an autoimmune reaction to myelin?

To top that off, my wife has an undiagnosed (or rather multiple different diagnoses) autoimmune condition against maybe connective tissue? Maybe against something else?

There is a possibility that both of our problems are the same unknown pathogen since she was a Veterinary Pathologist and could have been exposed to something weird that I caught. Her problem could be an unknown parasite since artemisia seems to help her cyclic episodes.

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TatumAH Offline OP
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Idiopathic Glycosuia

Idiopathic peripheral neuropathy, is common and is diagnosed by ruling out toxin exposure, lead, paint, etc and DM. The nerves to the feet are the longest in the body, and is a long supply line vulnerable to many many insults. So not DM neuropathy. CNS and PNS myelin are different, so doubt autoimmune neuropathy related to MS.

Some autoimmune conditions are related to molecular mimicry when some bacteria or virus resembles a human tissue antigen and mistakenly gets attacked!


Last edited by TatumAH; 02/20/21 05:25 AM.

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sevil regit
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Obviously I have a lot of relatively harmless defects. Renal glycosuria sounds like a winner. I am a little concerned about this:

Quote:
In most affected individuals, no treatment is required. However, some individuals with renal glycosuria may develop diabetes mellitus. (For further information, please see the "Related Disorders" section above.. Therefore, appropriate testing should be conducted to rule out diabetes and to regularly monitor those with confirmed renal glycosuria.


The problem is that doctors always look at A1C to tell if you have DM, but the renal glycosuria prevents a positive A1C! The two conditions could be unrelated, but having one prevents diagnosis of the other.

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TatumAH Offline OP
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The defect would likely prevent the complications of DM, as it's the long term elevation of serum glucose that causes all the problems to, vascular, renal, and nerves! In fact one of the newer treatments, i furget the trade name, is a medication that blocks the renal
re-absorption of glucose. and dumps glucose into the urine, improving the serum glucose levels.


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sevil regit
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Google to the rescue!

Canagliflozin, Dapagliflozin, and Empagliflozin, OH MY! That's why I couldn't remember their names, I would never waste brain RAM on a bunch of, pardon the term, Copycat drugs!

Quote:

Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. Medicines in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin. They are available as single-ingredient products and also in combination with other diabetes medicines such as metformin. SGLT2 inhibitors lower blood sugar by causing the kidneys to remove sugar from the body through the urine. The safety and efficacy of SGLT2 inhibitors have not been established in patients with type 1 diabetes, and FDA has not approved them for use in these patients.


Last edited by TatumAH; 02/20/21 09:10 PM.

There's nothing wrong with thinking
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sevil regit
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Cool! So I already have that capability without the expensive prescription.

Quote:
it's the long term elevation of serum glucose that causes all the problems to, vascular, renal, and nerves


I was hoping that was the case, but sometimes what we hope for is not the total situation.

On another good news topic, I like to watch TWIV (This Week In Virology) on YouTube. Once a week they hear from Dr. Griffin who is a honcho of docs treating Covid-19 patients every day. This week he mentioned the benefits of treating admitted patients with 25(OH)-Vitamin D, as discussed by the Spanish trials. He also mentioned this later when he was discussing GPs treating Covid19 outpatients instead of just sending them home to isolate until they either get better or worse and need hospitalization.

He also said people who get vaccinations and soon after discover they have been exposed right around that time, tend to do better than those who don't get vaccinations. So immunity may not begin much before 14 days post vaccination, but apparently just giving your immune system a few days jump on it's response is useful.

Some do that now with people bitten by rabid animals on the extremities, since the immune system can be faster than the rabies virus getting into the central nervous system. Facial bites are more urgent. They require quick treatment with antibodies.

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Finally got an appointment. Gonna git Phizerd on Wednesday.


You never change things by fighting the existing reality.
To change something, build a new model that makes the old model obsolete.
R. Buckminster Fuller
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TatumAH Offline OP
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dont get incisored


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sevil regit
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A wizard caint git incisored!


You never change things by fighting the existing reality.
To change something, build a new model that makes the old model obsolete.
R. Buckminster Fuller
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TatumAH Offline OP
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but maybe gizzard?

Last edited by TatumAH; 03/06/21 03:35 AM.

There's nothing wrong with thinking
Except that it's lonesome work
sevil regit
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