Today's Birthdays
There are no members with birthdays on this day.
Current Topics
A Musical Quiz
by Ken Condon - 11/30/21 12:34 AM
What's for dinner?
by TatumAH - 11/30/21 12:17 AM
I’ll Buy That
by Mellowicious - 11/29/21 10:34 PM
Denialism
by NW Ponderer - 11/29/21 10:33 PM
Winning
by perotista - 11/29/21 08:54 PM
RoundTable For Fall 2021
by pondering_it_all - 11/29/21 08:38 PM
Boundaries for Facebook
by Jeffery J. Haas - 11/29/21 12:38 AM
Pacific Northwest Weather
by pdx rick - 11/28/21 08:59 PM
A Fungus Amungus
by logtroll - 11/28/21 01:25 PM
Coronavirus: The Plague of The 21st Century?
by TatumAH - 11/28/21 06:19 AM
Republicans promise brutal revenge in 2022
by pdx rick - 11/27/21 08:45 PM
masks and vaccinations
by logtroll - 11/27/21 01:36 PM
Vigilantism - why isn’t it illegal?
by logtroll - 11/25/21 11:46 PM
"Mom, I think it's a boy."
by TatumAH - 11/25/21 04:37 AM
Gerrymandering
by perotista - 11/23/21 10:17 PM
You don't know beans! vs Killer Beans
by TatumAH - 11/23/21 08:37 PM
Moderna trying to ignore 1.5 billion dollar investment
by Jeffery J. Haas - 11/23/21 03:03 AM
Popular Topics(Views)
9,680,475 my own book page
4,778,796 We shall overcome
3,864,414 Campaign 2016
3,526,053 Trump's Trumpet
2,789,745 3 word story game
Previous Thread
Next Thread
Print Thread
Rate Thread
Page 3 of 10 1 2 3 4 5 9 10
Joined: Feb 2006
Posts: 11,479
Likes: 70
veteran
Offline
veteran
Joined: Feb 2006
Posts: 11,479
Likes: 70
So that's why dialysis patients die. Much more complicated than I thought.

I have a weird condition where I often have sugar in my urine, but I never have a positive A1C. If I eat a lot of sugar, my kidney's seem to piss it out very efficiently. This has always been the case, from childhood. I have a familial history of diabetes. I also have peripheral afferent neuropathy (numb feet) from myelin degeneration.

My neurologist says neuropathy is not a symptom of my MS. Is it possible to have diabetic neuropathy without a positive A1C? Or do I just have an autoimmune reaction to myelin?

To top that off, my wife has an undiagnosed (or rather multiple different diagnoses) autoimmune condition against maybe connective tissue? Maybe against something else?

There is a possibility that both of our problems are the same unknown pathogen since she was a Veterinary Pathologist and could have been exposed to something weird that I caught. Her problem could be an unknown parasite since artemisia seems to help her cyclic episodes.

Joined: Feb 2011
Posts: 1,363
Likes: 26
TatumAH Online Sick OP
member
OP Online Sick
member
Joined: Feb 2011
Posts: 1,363
Likes: 26
Idiopathic Glycosuia

Idiopathic peripheral neuropathy, is common and is diagnosed by ruling out toxin exposure, lead, paint, etc and DM. The nerves to the feet are the longest in the body, and is a long supply line vulnerable to many many insults. So not DM neuropathy. CNS and PNS myelin are different, so doubt autoimmune neuropathy related to MS.

Some autoimmune conditions are related to molecular mimicry when some bacteria or virus resembles a human tissue antigen and mistakenly gets attacked!


Last edited by TatumAH; 02/20/21 05:25 AM.

There's nothing wrong with thinking
Except that it's lonesome work
sevil regit
Joined: Feb 2006
Posts: 11,479
Likes: 70
veteran
Offline
veteran
Joined: Feb 2006
Posts: 11,479
Likes: 70
Obviously I have a lot of relatively harmless defects. Renal glycosuria sounds like a winner. I am a little concerned about this:

Quote:
In most affected individuals, no treatment is required. However, some individuals with renal glycosuria may develop diabetes mellitus. (For further information, please see the "Related Disorders" section above.. Therefore, appropriate testing should be conducted to rule out diabetes and to regularly monitor those with confirmed renal glycosuria.


The problem is that doctors always look at A1C to tell if you have DM, but the renal glycosuria prevents a positive A1C! The two conditions could be unrelated, but having one prevents diagnosis of the other.

Joined: Feb 2011
Posts: 1,363
Likes: 26
TatumAH Online Sick OP
member
OP Online Sick
member
Joined: Feb 2011
Posts: 1,363
Likes: 26
The defect would likely prevent the complications of DM, as it's the long term elevation of serum glucose that causes all the problems to, vascular, renal, and nerves! In fact one of the newer treatments, i furget the trade name, is a medication that blocks the renal
re-absorption of glucose. and dumps glucose into the urine, improving the serum glucose levels.


There's nothing wrong with thinking
Except that it's lonesome work
sevil regit
Joined: Feb 2011
Posts: 1,363
Likes: 26
TatumAH Online Sick OP
member
OP Online Sick
member
Joined: Feb 2011
Posts: 1,363
Likes: 26
Google to the rescue!

Canagliflozin, Dapagliflozin, and Empagliflozin, OH MY! That's why I couldn't remember their names, I would never waste brain RAM on a bunch of, pardon the term, Copycat drugs!

Quote:

Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors

SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. Medicines in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin. They are available as single-ingredient products and also in combination with other diabetes medicines such as metformin. SGLT2 inhibitors lower blood sugar by causing the kidneys to remove sugar from the body through the urine. The safety and efficacy of SGLT2 inhibitors have not been established in patients with type 1 diabetes, and FDA has not approved them for use in these patients.


Last edited by TatumAH; 02/20/21 09:10 PM.

There's nothing wrong with thinking
Except that it's lonesome work
sevil regit
Joined: Feb 2006
Posts: 11,479
Likes: 70
veteran
Offline
veteran
Joined: Feb 2006
Posts: 11,479
Likes: 70
Cool! So I already have that capability without the expensive prescription.

Quote:
it's the long term elevation of serum glucose that causes all the problems to, vascular, renal, and nerves


I was hoping that was the case, but sometimes what we hope for is not the total situation.

On another good news topic, I like to watch TWIV (This Week In Virology) on YouTube. Once a week they hear from Dr. Griffin who is a honcho of docs treating Covid-19 patients every day. This week he mentioned the benefits of treating admitted patients with 25(OH)-Vitamin D, as discussed by the Spanish trials. He also mentioned this later when he was discussing GPs treating Covid19 outpatients instead of just sending them home to isolate until they either get better or worse and need hospitalization.

He also said people who get vaccinations and soon after discover they have been exposed right around that time, tend to do better than those who don't get vaccinations. So immunity may not begin much before 14 days post vaccination, but apparently just giving your immune system a few days jump on it's response is useful.

Some do that now with people bitten by rabid animals on the extremities, since the immune system can be faster than the rabies virus getting into the central nervous system. Facial bites are more urgent. They require quick treatment with antibodies.

Joined: Apr 2010
Posts: 11,608
Likes: 52
L
veteran
Offline
veteran
L
Joined: Apr 2010
Posts: 11,608
Likes: 52
Finally got an appointment. Gonna git Phizerd on Wednesday.


You never change things by fighting the existing reality.
To change something, build a new model that makes the old model obsolete.
R. Buckminster Fuller
Joined: Feb 2011
Posts: 1,363
Likes: 26
TatumAH Online Sick OP
member
OP Online Sick
member
Joined: Feb 2011
Posts: 1,363
Likes: 26
dont get incisored


There's nothing wrong with thinking
Except that it's lonesome work
sevil regit
Joined: Apr 2010
Posts: 11,608
Likes: 52
L
veteran
Offline
veteran
L
Joined: Apr 2010
Posts: 11,608
Likes: 52
A wizard caint git incisored!


You never change things by fighting the existing reality.
To change something, build a new model that makes the old model obsolete.
R. Buckminster Fuller
Joined: Feb 2011
Posts: 1,363
Likes: 26
TatumAH Online Sick OP
member
OP Online Sick
member
Joined: Feb 2011
Posts: 1,363
Likes: 26
but maybe gizzard?

Last edited by TatumAH; 03/06/21 03:35 AM.

There's nothing wrong with thinking
Except that it's lonesome work
sevil regit
Page 3 of 10 1 2 3 4 5 9 10

Link Copied to Clipboard
Who's Online Now
0 members (), 41 guests, and 1 robot.
Key: Admin, Global Mod, Mod
Newest Members
SuZQ2, KevFilthyANML, Risky, Gladys G. Jackson, Beach Baby
6,297 Registered Users
Forum Statistics
Forums61
Topics17,252
Posts312,859
Members6,297
Most Online294
Dec 6th, 2017
Powered by UBB.threads™ PHP Forum Software 7.7.5
(Release build 20201027)
Responsive Width:

PHP: 7.4.26 Page Time: 0.013s Queries: 36 (0.005s) Memory: 3.0350 MB (Peak: 3.2529 MB) Data Comp: Zlib Server Time: 2021-11-30 00:43:28 UTC
Valid HTML 5 and Valid CSS