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RoundTable For Fall 2021
by TatumAH - 10/22/21 03:47 AM
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Why and How can they?
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A Fungus Amungus
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Carbon Sequestration
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Winning
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Where did this car thing start?
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Mountain Meadows Massacre
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Divorce: American Style
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Who killed General Colin Powell?
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A Musical Quiz
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What about the latest Catholic Church fiasco in France?
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Southwest, American among Texas businesses defying governor
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Biden Administration Threads not in Current Topics
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Arizona Audit/Recount 2020 election
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I've heard growing your own medicine makes it more of a sacrament, like Native American shamans gathering peyote.

Last edited by pondering_it_all; 08/13/20 07:11 PM. Reason: spelling
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Carpal Tunnel
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This shaman has set aside his vestments and left the hunting and gathering to others.


Good coffee, good weed, and time on my hands...
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Interesting news today: A paper just came out that studied remdesivir given early, in the viral replication phase of Covid. This is after exposure and before any severe symptoms, like in the first week. The test arm got three infusions of remdesivir and the control arm got placebo. Remdesivir was 87% effective in reducing hospitalizations! So it actually DOES work, but only when there is replicating virus for it to stop.

If you give it later, it's not very effective at all, only shortening virus clearance time by a couple of days. Not preventing hospitalizations or death. This phenomenon is very familiar: Researchers assumed Covid was one "disease" and death was caused by the virus "winning". So a lot of their trials and treatments used drugs under test on the most ill patients. (And FDA Emergency Use approval enforced this!) The only drug found back then to help was dexamethasone, a steroid known to make viral infections worse. Doctors started looking at various clues that Covid was actually two different diseases: Viral infection, followed by immune system over-reaction. So all antiviral drug trials that started after most of the virus was inactivated were useless.

Monoclonal antibodies work the same way: They are quite effective, but only in the first week after exposure. So maybe some other "antiviral" drugs are actually effective in that first "golden hour". It would be ironic if studies found that HCQ+zinc, and ivermectin worked during this same phase. This was Dr. Marik's criticism of groups that failed to replicate his IV Vitamin C for septic shock treatment: He said they started that therapy days late, when it was an ER "first hour" treatment.


We're flying electric helicopters on Mars yet you can't turn on your clothes dryer in Texas. That's because scientists are in charge of Mars, and Republicans are in charge of Texas.
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Originally Posted by pondering_it_all
...Monoclonal antibodies work the same way: They are quite effective, but only in the first week after exposure.
Yesterday, on NPR's Morning Edition, Monoclonal antibody treatment was discussed. Turns out the unvaxxed who didn't want to take the vaxx because it is "experimental" will gladly take experimental Monoclonal antibody therapy!

You can't make this stuff up.

So, these fools forgo a $10 "experimental" vaccination, for a $2,500 "experimental" treatment + $30,000 hospital stay. Sounds just like a Conservative. rolleyes


Contrarian, extraordinaire


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Life is an experiment and there is no control...


You never change things by fighting the existing reality.
To change something, build a new model that makes the old model obsolete.
R. Buckminster Fuller
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And the process for making monoclonal antibodies is pretty damned scary: They fuse Covid-exposed mouse spleen B-cells with human myeloma cancer cells to make "Frankenstein" hybridoma cells. Those reproduce in a vat and continue making the antibody. As opposed to getting the vaccine, and making your own antibodies.

The antibodies you end up with are mouse antibodies, and they only last about three months. If you were exposed to the SARS-COV2 virus, your T and B cells might get activated but they might not. So you may not end up with any long lasting protection.

Personally, I might not react well since I'm pretty allergic to mice. The (relatively) good news is they have been experimenting with a single subcutaneous injection of MAB instead of three IV infusions. That makes it something you could get in the ER during your initial visit, with just a small wait to see if you get anaphylactic shock before going home.


We're flying electric helicopters on Mars yet you can't turn on your clothes dryer in Texas. That's because scientists are in charge of Mars, and Republicans are in charge of Texas.
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