In 2022 the Democrats are going to face, literally, crazy Trump infested crazy people who don't deal well with reality. Seems to me that should give the Dems some help.
It depends on whether Republicans are able to demonize Biden in the eyes of the general public. Thus far they are leaving him alone and demonizing Mitt Romney and Liz Cheney.
They are in the act of purging all moderates from the party.
Americans didn't like Trump when he was in office and they don't like him now. I don't think it's going to play well in the midterms.