Without your factors taken into consideration...
Those factors need
to be considered - because they affect election outcomes.
This fact alone:
The number of COvID related deaths is nearing DeSantis' margin of victory in 2018.
...tells you COVID deaths need to be factored.
There were four polls conducted in Florida in August, none in September. Rubio has the lead over Demmings by 6.5 points averaging all four out. More importantly is Rubio is winning the independent vote by an average of 48-43 with 9% undecided. Add the independent vote along with the PVI of R+3 for Florida, the 6.5 point lead is right on.
On the hand, D Charlie Crist leads R DeSantis in the governors race by 12 points, 52-40. Rest undecided. Bottom line, Rubio is popular, DeSantis isn't. A majority of voters by a 51-46 margin think DeSantis cares more about running for the presidency than the future of Florida. COVID, 43% of Floridan's have a favorable view of how DeSantis is handling COVID, 53% unfavorable.
Bottom line, it seems the dislike of DeSantis hasn't effect Rubio. At least not yet.