Peyote is pretty horrible. Very hard on your stomach. Puking is part of the experience. Extraction of the mescaline is very easy, and mescaline is lovely. It's 3,4,5-Trimethoxyphenethylamine, and 3,4.5-Trimethoxyamphetamine is lovely, too. Almost identical. There are lots of complex amphetamines that are fun with slight differences:

2,5-Dimethoxy-4-methylamphetamine is STP
3,4-Methylenedioxyamphetamine is MDA
3,4-Methyl​enedioxy​methamphetamine is MDMA AKA ecstasy or molly

All of these lack the puking part of the peyote experience, with similar psychedelic effects. Effective doses vary a lot.

The big difference is that mushrooms are legal in Washington state. The rest of these are still illegal everywhere in the US.

We're flying electric helicopters on Mars yet you can't turn on your clothes dryer in Texas. That's because scientists are in charge of Mars, and Republicans are in charge of Texas.