Let's see what happens with the voting rights bill, before we hold the funeral. Democrats are talking about changing to a talking filibuster or passing a carve-out so filibusters do not apply to voting rights bills, just like Republicans did when they changed the Senate rules to get rid of filibusters against Supreme Court nominee confirmation. Manchin has previously expressed some openness to such changes.
Manchin and Senema should consider that unless the voting rights bill gets passed, THEY will not be reelected! They also might want to look at all the people running for Senator in 2022: I think every one of them wants to dump the filibuster. So if Democrats gain just two more seats, Manchin and Senema are outvoted.